Sub-10 nm gold nanoparticles promote adipogenesis and inhibit osteogenesis of mesenchymal stem cells
作者： Jingchao Li , Ying Chen , Yingjun Yang , Naoki Kawazoe , Guoping Chen
DOI: 10.1039/C6TB03276A
关键词:
摘要: Sub-10 nm gold nanoparticles (Au NPs) have attracted extensive attention for different biomedical applications because of their small size. However, the influence NPs on differentiation human bone marrow-derived mesenchymal stem cells (hMSCs) is unclear. In this study, 4 Au (Au4-mPEG were synthesized to investigate osteogenic and adipogenic hMSCs 40-nm counterparts (Au40-mPEG used comparison. Different from Au40-mPEG NPs, Au4-mPEG reduced ALP activity, calcium deposition marker gene expression, while increased oil droplet formation expression in hMSCs. The mechanism study indicated that NP treatment did not affect cellular mechanical property significantly but induced a high level reactive oxygen species (ROS). results provide some insights into sub-10 cell functions these particles tissue engineering.
rsc.org
sci-hub.se 参考文章(43)
Jingchao Li, Rong Cai, Naoki Kawazoe, Guoping Chen, Facile preparation of albumin-stabilized gold nanostars for the targeted photothermal ablation of cancer cells Journal of Materials Chemistry B. ,vol. 3, pp. 5806- 5814 ,(2015) , 10.1039/C5TB00633C
Seon Young Choi, Min Seok Song, Pan Dong Ryu, Anh Thu Ngoc Lam, Sang-Woo Joo, So Yeong Lee, None, Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway International Journal of Nanomedicine. ,vol. 10, pp. 4383- 4392 ,(2015) , 10.2147/IJN.S78775
Hongli Mao, Jingchao Li, Ida Dulińska-Molak, Naoki Kawazoe, Yoshihiko Takeda, Hiroaki Mamiya, Guoping Chen, Cellular effects of magnetic nanoparticles explored by atomic force microscopy Biomaterials Science. ,vol. 3, pp. 1284- 1290 ,(2015) , 10.1039/C5BM00141B
Yiyun Cao, Yao He, Hui Liu, Yu Luo, Mingwu Shen, Jindong Xia, Xiangyang Shi, Targeted CT imaging of human hepatocellular carcinoma using low-generation dendrimer-entrapped gold nanoparticles modified with lactobionic acid Journal of Materials Chemistry B. ,vol. 3, pp. 286- 295 ,(2015) , 10.1039/C4TB01542H
Francis H. Glorieux, Frank Rauch, Horacio Plotkin, Leanne Ward, Rose Travers, Peter Roughley, Ljiljana Lalic, Delphine F. Glorieux, François Fassier, Nicholas J. Bishop, Type V osteogenesis imperfecta: a new form of brittle bone disease. Journal of Bone and Mineral Research. ,vol. 15, pp. 1650- 1658 ,(2000) , 10.1359/JBMR.2000.15.9.1650
Gianni Ciofani, Leonardo Ricotti, Claudio Canale, Delfo D’Alessandro, Stefano Berrettini, Barbara Mazzolai, Virgilio Mattoli, Effects of barium titanate nanoparticles on proliferation and differentiation of rat mesenchymal stem cells. Colloids and Surfaces B: Biointerfaces. ,vol. 102, pp. 312- 320 ,(2013) , 10.1016/J.COLSURFB.2012.08.001
B. Devika Chithrani, Arezou A. Ghazani, Warren C. W. Chan, Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Letters. ,vol. 6, pp. 662- 668 ,(2006) , 10.1021/NL052396O
Chien-Tsun Chen, Yu-Ru V Shih, Tom K Kuo, Oscar K Lee, Yau-Huei Wei, None, Coordinated Changes of Mitochondrial Biogenesis and Antioxidant Enzymes During Osteogenic Differentiation of Human Mesenchymal Stem Cells Stem Cells. ,vol. 26, pp. 960- 968 ,(2008) , 10.1634/STEMCELLS.2007-0509
Jingchao Li, Xiangyang Shi, Mingwu Shen, Hydrothermal Synthesis and Functionalization of Iron Oxide Nanoparticles for MR Imaging Applications Particle & Particle Systems Characterization. ,vol. 31, pp. 1223- 1237 ,(2014) , 10.1002/PPSC.201400087
Takashi Hoshiba, Naoki Kawazoe, Tetsuya Tateishi, Guoping Chen, Development of extracellular matrices mimicking stepwise adipogenesis of mesenchymal stem cells. Advanced Materials. ,vol. 22, pp. 3042- 3047 ,(2010) , 10.1002/ADMA.201000038