Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment

摘要: Study Type – Therapy (case series) Level of Evidence 4 OBJECTIVE •  To explore whether levels nerve growth factor (NGF) in expressed prostatic secretions (EPS) are correlated with symptom severity chronic prostatitis (CP) and pelvic pain syndrome (CPPS). PATIENTS AND METHODS •  All patients CP/CPPS underwent a complete history physical examination, were scored according to the National Institutes Health Chronic Prostatitis Symptom Index (NIH-CPSI). •  Expressed secretion samples from 20 four asymptomatic control collected frozen, NGF EPS measured by enzyme-linked immunosorbent assay. •  Patients asked NIH-CPSI questionnaires at baseline 8 weeks after treatment least 25% decrease total score values classified as responders treatment. RESULTS •  The mean (±sd) 7409 (±3788) pg/mL 4174 (±1349) pg/mL, respectively. The level directly (P= 0.014, r= 0.541). •  There no significant differences between before treatment. However, successful significantly decreased 0.001). CONCLUSION •  Nerve might contribute pathophysiology changes occurred proportion severity. Therefore, these results suggest that could be used new biomarker evaluate symptoms effects