Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis

作者: H. z. Hausen

DOI: 10.1093/JNCI/92.9.690

关键词:

摘要: During the past 20 years, several types of human papillomaviruses (HPVs) have been identified that cause specific cancers. The etiology cancer cervix has linked to HPV, with a high preponderance HPV16. role these virus infections established 1) by regular presence HPV DNA in respective tumor biopsy specimens, 2) demonstration viral oncogene expression (E6 and E7) material, 3) identification transforming properties genes, 4) requirement for E6 E7 maintaining malignant phenotype cervical carcinoma cell lines, 5) interaction oncoproteins growth-regulating host-cell proteins, 6) epidemiologic studies pointing as major risk factor development. In addition cervix, proportion anal, perianal, vulvar, penile cancers appears be same infections. addition, close 20% oropharyngeal contain from HPV. Recent evidence also points possible other squamous carcinomas skin. This review covers recent developments understanding molecular mechanisms carcinogenesis, mainly discussing functions regulation oncogenes factors. Modifications most likely engaged control gene proliferating cells, emerge important events HPV-mediated carcinogenesis.

参考文章(111)
P. Hawley-Nelson, K.H. Vousden, N.L. Hubbert, D.R. Lowy, J.T. Schiller, HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. The EMBO Journal. ,vol. 8, pp. 3905- 3910 ,(1989) , 10.1002/J.1460-2075.1989.TB08570.X
J. K. McDougall, Immortalization and Transformation of Human Cells by Human Papillomavirus Current Topics in Microbiology and Immunology. ,vol. 186, pp. 101- 119 ,(1994) , 10.1007/978-3-642-78487-3_6
M. Scheffner, H. Romanczuk, K. Münger, J. M. Huibregtse, J. A. Mietz, P. M. Howley, Functions of human papillomavirus proteins. Current Topics in Microbiology and Immunology. ,vol. 186, pp. 83- 99 ,(1994) , 10.1007/978-3-642-78487-3_5
Kamath P, Weil Mm, Zhang S, Chen Z, Shillitoe Ej, Effectiveness of three ribozymes for cleavage of an RNA transcript from human papillomavirus type 18. Cancer Gene Therapy. ,vol. 2, pp. 263- ,(1995)
R N Eisenman, B Lüscher, D A Galloway, J M Firzlaff, The E7 protein of human papillomavirus type 16 is phosphorylated by casein kinase II. The New biologist. ,vol. 1, pp. 44- 53 ,(1989)
E.-M. de Villiers, Human Pathogenic Papillomavirus Types: An Update Current Topics in Microbiology and Immunology. ,vol. 186, pp. 1- 12 ,(1994) , 10.1007/978-3-642-78487-3_1
P.H. Smits, H.L. Smits, R.P. Minnaar, B.A. Hemmings, R.E. Mayer-Jaekel, R. Schuurman, J. van der Noordaa, J. ter Schegget, The 55 kDa regulatory subunit of protein phosphatase 2A plays a role in the activation of the HPV16 long control region in human cells with a deletion in the short arm of chromosome 11. The EMBO Journal. ,vol. 11, pp. 4601- 4606 ,(1992) , 10.1002/J.1460-2075.1992.TB05562.X
M. J. Antinore, M. J. Birrer, D. Patel, L. Nader, D. J. McCance, The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors. The EMBO Journal. ,vol. 15, pp. 1950- 1960 ,(1996) , 10.1002/J.1460-2075.1996.TB00546.X
Sibylle Seagon, Matthias Dürst, Genetic Analysis of an in Vitro Model System for Human Papillomavirus Type 16-associated Tumorigenesis Cancer Research. ,vol. 54, pp. 5593- 5598 ,(1994)