作者: H. z. Hausen
关键词:
摘要: During the past 20 years, several types of human papillomaviruses (HPVs) have been identified that cause specific cancers. The etiology cancer cervix has linked to HPV, with a high preponderance HPV16. role these virus infections established 1) by regular presence HPV DNA in respective tumor biopsy specimens, 2) demonstration viral oncogene expression (E6 and E7) material, 3) identification transforming properties genes, 4) requirement for E6 E7 maintaining malignant phenotype cervical carcinoma cell lines, 5) interaction oncoproteins growth-regulating host-cell proteins, 6) epidemiologic studies pointing as major risk factor development. In addition cervix, proportion anal, perianal, vulvar, penile cancers appears be same infections. addition, close 20% oropharyngeal contain from HPV. Recent evidence also points possible other squamous carcinomas skin. This review covers recent developments understanding molecular mechanisms carcinogenesis, mainly discussing functions regulation oncogenes factors. Modifications most likely engaged control gene proliferating cells, emerge important events HPV-mediated carcinogenesis.