A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction.

摘要: Interleukin-6 (IL-6) is a pleiotropic cytokine that plays central role in the pathogenesis of stroke. A base pair substitution -174G/C promoter region IL-6 gene regulates expression. We compared prevalence this polymorphism patients with lacunar stroke and an age- sex-matched cohort asymptomatic controls. Eighty-two 82 controls were prospectively assessed genotyped for gene. Demographics vascular risk factors recorded both groups. brain computed tomography scan/magnetic resonance imaging confirmed clinical diagnosis all patients. The CC genotype (18.3 vs. 7.3%, P=0.03), frequency C allele (42.7 31.1%, P=0.03) statistically significantly higher than Expectedly, had logistic regression model showed independent variables associated included history hypertension (odds ratio (OR), 7.02; 95% confidence interval (95% CI), 3.11-15.81), diabetes (OR, 5.37; CI, 1.52-8.89), hyperlipidemia 3.43; 1.04-11.25), smoking 5.84; 2.15-15.84), 4.28; 1.22-15.00). These findings suggest might result from genetic susceptibility to inflammation-mediated damage concert atherosclerotic factors.