Evolution of the ferritin family in vertebrates

摘要: Ferritins are ubiquitous, highly-conserved proteins that constitute one of the most important components cellular machinery devoted to management iron levels. Various ferritins have been described in vertebrates, though their exact functions and phylogenetic relationships remain be established. Our attempts properly annotate two ferritin subunits isolated from Asian sea bass Lates calcarifer, prompted us investigate evolutionary among vertebrate with non-vertebrate homologs. We carried out a detailed screening mined sequences by examining regulatory elements gene structures. Subsequently, we performed comprehensive analyses involving various metazoan chain types, respectively. suggest single duplicated early vertebrates types species evolved independently through lineage-specific duplications. Notably, this includes mitochondrial found only insects mammals show result parallel duplications followed convergent events targeting. Regarding cytosolic chains our results scenario duplication at base more recent teleosts amphibians. This implies light is orthologous middle teleosts, contrast previous claims paralogous relationship coupled differential loss. hypothesise extensive differences sequence function between these may driven adaptation tetrapods terrestrial environments, which involved changes dynamics uptake storage. Altogether, clarify pave way for interpretation functional adaptations within an framework.