Penetration enhancing effects of selected natural oils utilized in topical dosage forms
作者： Joe M. Viljoen , Amé Cowley , Jan du Preez , Minja Gerber , Jeanetta du Plessis
DOI: 10.3109/03639045.2015.1047847
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摘要: AbstractContext: Various natural products, including oils, have been utilized as penetration enhancers due to their “safety profiles”. These oils contain fatty acids promoting skin permeability through lipid fluidization within the stratum corneum; and might therefore be able effectively enhance transdermal drug delivery.Objective: We investigated possible enhancing properties of selected utilizing flurbiprofen marker compound in emulgel formulations. The formulations were compared a liquid paraffin hydrogel establish any significant effects.Methods: Gas chromatographic analysis was performed at ambient temperature determine acid composition each oils. Franz cell diffusion studies tape stripping methods employed study delivery into, skin.Results: following rank order for flux-values obtained: Hydrogel >>>> olive oil >> p...
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