Adsorptive Pinocytosis of Epidermal Growth Factor: Studies of its Relevance to Mitogenesis

摘要: Cell growth in vitro depends on an adequate supply of minerals, nutrients, factors and modulators. Peptide hormones are chemical mediators the response (Bradshaw, 1978; Smith Temin, 1974; Gospodarowicz Moran, 1976; Chen Buchanan, 1975), but spite concerted efforts many, molecular details their modes action remain substantially undefined. Little evidence has accumulated to implicate receptor-coupled membrane transduction mechanisms like stimulation adenylate cyclase or redistribution divalent cations as primary intracellular effectors. Indeed, very nature delayed responses cell may indicate that alternative forms regulation applicable.