Apomorphine effect on pain threshold in Parkinson's disease: a clinical and positron emission tomography study.
作者： Estelle Dellapina , Angélique Gerdelat-Mas , Fabienne Ory-Magne , Laure Pourcel , Monique Galitzky
DOI: 10.1002/MDS.23406
关键词:
摘要: Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect apomorphine versus placebo on thresholds and pain-induced cerebral activity 25 patients PD. Subjective threshold (using thermal stimulation, thermotest), objective (nociceptive flexion reflex), (H(2)(15)O PET) during noxious innocuous stimulations were performed. Neither subjective nor activation profile modified by PD patients. Apomorphine has no processing We suggest other monoamine systems than dopaminergic system involved.
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