Angiotensin-Converting Enzyme 2: Central Regulator for Cardiovascular Function
作者： Huijing Xia , Eric Lazartigues
DOI: 10.1007/S11906-010-0105-7
关键词:
摘要: Angiotensin-converting enzyme 2 (ACE2) is a new component of the renin-angiotensin system (RAS). Accumulating evidence shows that ACE2 provides protective effects in peripheral tissues and has great potential for treatment RAS-related diseases. The role central nervous not well established. However, recent years, much more progress been made on studies this carboxypeptidase regulation blood pressure cardiovascular function general. It shown brain interacts with other components RAS (ACE, angiotensin II, II type 1 receptor), protects baroreflex autonomic function, stimulates nitric oxide release, reduces oxidative stress, prevents development or attenuates hypertension. These data support critical function. This review summarizes recently published
springer.com
sci-hub.se 参考文章(42)
Eric D Lazartigues, Lie Gao, Wei Wang, Irving H Zucker, Rachael Farrar, Selective over expression of central ACE2 prevents baroreflex dysfunction in the chronic heart failure The FASEB Journal. ,vol. 23, ,(2009) , 10.1096/FASEBJ.23.1_SUPPLEMENT.610.2
Zhanyi Lin, Yanfang Chen, Wenfeng Zhang, Alex F. Chen, Shuguang Lin, Mariana Morris, RNA interference shows interactions between mouse brainstem angiotensin AT1 receptors and angiotensin‐converting enzyme 2 Experimental Physiology. ,vol. 93, pp. 676- 684 ,(2008) , 10.1113/EXPPHYSIOL.2007.041657
Debra I. Diz, Maria A. Garcia-Espinosa, Stephen Gegick, Ellen N. Tommasi, Carlos M. Ferrario, E. Ann Tallant, Mark C. Chappell, Patricia E. Gallagher, Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats. Experimental Physiology. ,vol. 93, pp. 694- 700 ,(2008) , 10.1113/EXPPHYSIOL.2007.040261
Huijing Xia, Yumei Feng, Teresa D. Obr, Peter J. Hickman, Eric Lazartigues, Angiotensin II Type 1 Receptor–Mediated Reduction of Angiotensin-Converting Enzyme 2 Activity in the Brain Impairs Baroreflex Function in Hypertensive Mice Hypertension. ,vol. 53, pp. 210- 216 ,(2009) , 10.1161/HYPERTENSIONAHA.108.123844
Junhui Tan, Hao Wang, Frans H. H. Leenen, Increases in brain and cardiac AT1 receptor and ACE densities after myocardial infarct in rats American Journal of Physiology-heart and Circulatory Physiology. ,vol. 286, ,(2004) , 10.1152/AJPHEART.00858.2003
Dan Harmer, Maureen Gilbert, Richard Borman, Kenneth L Clark, Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme FEBS Letters. ,vol. 532, pp. 107- 110 ,(2002) , 10.1016/S0014-5793(02)03640-2
Mohan K Raizada, Anderson J Ferreira, ACE2: A New Target for Cardiovascular Disease Therapeutics Journal of Cardiovascular Pharmacology. ,vol. 50, pp. 112- 119 ,(2007) , 10.1097/FJC.0B013E3180986219
Jie Lu, Yingdong Zhang, Jingping Shi, Effects of intracerebroventricular infusion of angiotensin-(1-7) on bradykinin formation and the kinin receptor expression after focal cerebral ischemia-reperfusion in rats. Brain Research. ,vol. 1219, pp. 127- 135 ,(2008) , 10.1016/J.BRAINRES.2008.04.057
Yumei Feng, Xinping Yue, Huijing Xia, Sharell M. Bindom, Peter J. Hickman, Catalin M. Filipeanu, Guangyu Wu, Eric Lazartigues, Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circulation Research. ,vol. 102, pp. 729- 736 ,(2008) , 10.1161/CIRCRESAHA.107.169110
Mary Donoghue, Frank Hsieh, Elizabeth Baronas, Kevin Godbout, Michael Gosselin, Nancy Stagliano, Michael Donovan, Betty Woolf, Keith Robison, Raju Jeyaseelan, Roger E. Breitbart, Susan Acton, A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9 Circulation Research. ,vol. 87, ,(2000) , 10.1161/01.RES.87.5.E1