Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 are involved in sinoaortic denervation-induced cardiovascular hypertrophy in rats.
作者： Li-Chao Zhang , Zhen-Zhen Li , Yong-Sheng Yu , Zhi-Bin Wang , Xin Wei
DOI: 10.1248/BPB.34.1398
关键词:
摘要: The balance of angiotensin-converting enzyme (ACE) and 2 (ACE2) in high blood pressure variability (BPV) induced cardiovascular hypertrophy remains elusive. aim the present work was to investigate expression activity ACE ACE2 heart aorta sinoaortic denervation (SAD) rats with BPV normal BP, explore potential role BPV-induced damage. Hemodynamics, hypertrophy, angiotensin II (Ang II) concentrations, were determined. Cardiac-tissue assayed by real-time polymerase chain reaction Western blot. Compared sham-operated rats, systolic diastolic increased baroreflex sensitivity decreased significantly SAD rats. presented obvious characterized ratio left ventricle weight body aortic length aorta. There no difference plasma Ang concentration between cardiac expression, elevated significant expressions demonstrated that It is tissue rather than circulating renin-angiotensin system contributes hypertrophy.
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