Respiratory syncytial virus infection in infants in rural Nepal

摘要: Summary Objectives Respiratory syncytial virus (RSV) pneumonia is a leading cause of infant mortality worldwide. The risk RSV infection associated with preterm birth not well-characterized in resource-limited settings. We aimed to obtain precise estimates factors and disease burden infants rural southern Nepal. Methods Pregnant women were enrolled, along their infants, followed six months after active weekly home-based surveillance for acute respiratory illness (ARI). Mid-nasal swabs obtained tested by PCR all episodes. Birth outcomes assessed at postpartum home visit. Results 311 (9%) 3509 had an ARI. ARI incidence decreased from 551/1000 person-years born between 28 31 weeks 195/1000 full-term (p = 0.017). Of 220 (71%) evaluated the health system, 41 (19%) visited hospital or physician. 287 assessment performed, 203 lower tract infection. Conclusions In south Asian setting intensive surveillance, caused significant illness. Preterm highest ARI, should be considered priority group preventive interventions