Incidence and Risk Factors for Respiratory Syncytial Virus and Human Metapneumovirus Infections among Children in the Remote Highlands of Peru

摘要: The disease burden and risk factors for respiratory syncytial virus (RSV) human metapneumovirus (MPV) infections among children living in remote, rural areas remain unclear.; We conducted a prospective, household-based cohort study of aged >3 years remote highland communities San Marcos, Cajamarca, Peru. Acute illnesses (ARI), including lower tract infection (LRTI), were monitored through weekly household visits from March 2009 September 2011. Nasal swabs collected during ARI/LRTI tested RSV, MPV, other viruses using real-time RT-PCR. Incidence rates rate ratios calculated mixed effects Poisson regression.; Among 892 enrolled children, incidence RSV MPV ARI 30 17 episodes per 100 child-years, respectively. proportions that presented as LRTI 12.5% 8.9%, Clinic hospitalizations significantly more frequent (all p values >0.05) with (clinic 41% hospital 5.3%) (38% 3.5%) when compared viral (23% 0.7%) without detected (24% 0.6%). In multivariable analysis, detection included younger age (RR 1.02, 95% CI: 1.00-1.03), the presence smoker house 1.63, 1.12-2.38), residing at higher altitudes 1.93, 1.25-3.00 2nd to 1st quartile residents; RR 1.98, 1.26-3.13 3rd residents). Having an unemployed head was associated 2.11, 1.12-4.01).; high altitude Peru, childhood due or common morbidity than no detections. identified this may be considered interventional studies control by these young developing countries.