Establishment of a concept of visceral fat syndrome and discovery of adiponectin.

摘要: Although obesity is a major background of life style-related diseases such as diabetes mellitus, lipid disorder, hypertension and cardiovascular disease, the extent whole body fat accumulation does not necessarily determinant for occurrence these diseases. We developed method analysis using CT scan established concept visceral obesity, in other word metabolic syndrome which intra-abdominal has an important role development diabetes, atherosclerosis. In order to clarify mechanism that causes diseases, we have analyzed gene expression profile subcutaneous adipose tissue tissue. From analysis, found tissue, especially expressed abundantly genes encoding bioactive substances cytokines, growth factors complements. addition known substances, novel collagen-like protein named adiponectin. Adiponectin present plasma at very high concentration inversely associated with accumulation. anti-diabetic, anti-hypertensive anti-atherogenic properties recent studies revealed this anti-inflammatory anti-oncogenic function. Therefore hypoadiponectinemia induced by should become strong risk factor also some kinds cancers.In review article, I would like discuss focusing on dysregulation adiponectin related obesity.