Spinal cord ependymomas with MYCN amplification show aggressive clinical behavior
作者： Amy A Swanson , Aditya Raghunathan , Robert B Jenkins , Martina Messing-Jünger , Torsten Pietsch
DOI: 10.1093/JNEN/NLZ064
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摘要: Adult spinal cord ependymomas are typically low grade and have a relatively favorable clinical course following gross total resection. We report 4 cases of anaplastic ependymoma with MYCN amplification, an exceptionally rare finding. All occurred in the adolescent young adult women had morphological immunohistochemical features (World Health Organization III). Chromosomal microarray analysis demonstrated amplification 2p24 (including MYCN) all cases. One patient died 6 months after surgery. Another recently removal metastatic nodules thoracic region, resection adjuvant radiation therapy lumbar 1 year previously. responded well chemotherapy but multiple relapses 82 diagnosis. found reported 2 other ependymomas, both arising females (Brain Pathol 2001;11:133-43). recurrences intracranial metastasis. Although is current previously suggest that this associated higher-grade histology, location, often unfavorable prognosis. The significance therapeutic implications require further evaluation.
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