Influence of gender and menopausal status on gut microbiota.

摘要: Abstract Objectives We explore the differences in gut microbiota associated with gender and hormonal status. Study design included 76 individuals this study: 17 pre-menopausal women, 19 men matched by age, as a control group for 20 post-menopausal women age women; all 4 groups were also body mass index (BMI) nutritional background. Main measurements analyzed microbiota, endotoxemia, intestinal incretins, pro-inflammatory cytokines, plasma levels of energy homeostasis regulatory hormones between pre- compared them their respective male groups. Results found higher Firmicutes/Bacteroidetes ratio, relative abundance Lachnospira Roseburia, GLP-1 than who had similar to men. In contrast, we observed lower Prevotella, Parabacteroides Bilophila genera, IL-6 MCP-1 GiP leptin men, irrespective menopausal status women. addition, adiponectin corresponding age-matched group. Conclusions Our results suggest that composition genders different may be related sexual dimorphism incidence metabolic diseases co-morbidities.