Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease.
作者： P. Factor-Litvak , E. Susser , K. Kezios , I. McKeague , J. D. Kark
关键词:
摘要: BACKGROUND AND OBJECTIVE: In adults, leukocyte telomere length (LTL) is variable, familial, and longer in women offspring conceived by older fathers. Although short LTL associated with atherosclerotic cardiovascular disease, long major cancers. The prevailing notion that a “telomeric clock,” whose movement (expressed attrition) reflects the pace of aging. Accordingly, individuals are considered to be biologically than their peers. Recent studies suggest largely determined before adulthood. We examined whether factors characterize adults also influence newborns. METHODS: was measured blood samples from 490 newborns parents. RESULTS: (mean ± SD) (9.50 0.70 kb) mothers (7.92 0.67 fathers (7.70 0.71 (both P r = 0.47; 0.36; for interaction .02). Newborn 0.144 kb girls boys ( .02), 0.175 .0086). CONCLUSIONS: large variation across challenges telomeric clock model. Having inherently or may at birth, anteceding decades disease manifestation adults.
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