TRP functions in the broncho-pulmonary system.

摘要: The current understanding of the role transient receptor potential (TRP) channels in airways and lung was initially based on localization a series such subset sensory nerve fibers respiratory tract. Soon after, TRP channel expression function have been identified nonneuronal cells. In these two locations, TRPs regulate physiological processes aimed at integrating different stimuli to maintain homeostasis react harmful agents tissue injury by building up inflammatory responses repair processes. There is no doubt that localized network contribute airway neurogenic inflammation, emerging evidence underlines orchestrating inflammation However, recent basic clinical studies offered clues regarding contribution neuronal mechanism asthma, chronic obstructive pulmonary disease, idiopathic fibrosis, cough, other diseases.