Postprandial and orthostatic hypotension in Parkinson's disease

摘要: In this study, the 24-hour pattern of blood pressure (BP), heart rate, and urinary catecholamine (CA) excretion response BP plasma CA to tilt test have been investigated in 13 untreated patients affected by Parkinson's disease (PD) 11 age-matched healthy controls. Seven PD subjects showed a fall supine systolic greater than that controls (ie, exceeding 20% preprandial value). A significant relationship was found group between degree postprandial hypotension mean value dopamine excretion. Eight also orthostatic during (performed morning hours) phase. Basal norepinephrine levels patients, as well their percentage increases on standing, were within range These data suggest existence subtype patient, characterized widespread impairment cardiovascular responsiveness bordering syndromes autonomic failure such progressive or multiple system atrophy, both.