siRNA-Mediated Down-Regulation of P-glycoprotein in a Xenograft Tumor Model in NOD-SCID Mice
作者： Meysam Abbasi , Hamidreza Montazeri Aliabadi , Elaine H. Moase , Afsaneh Lavasanifar , Kamaljit Kaur
DOI: 10.1007/S11095-011-0480-Z
关键词:
摘要: Purpose The efficacy of chemotherapy is decreased due to over-expression the drug transporter P-glycoprotein (P-gp). This study was conducted determine feasibility down-regulating tumor P-gp levels with non-viral siRNA delivery in order sensitize tumors therapy.
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