Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy
作者： Adam D. Pfefferle , Benjamin T. Spike , Geoff M. Wahl , Charles M. Perou
DOI: 10.1007/S10549-014-3262-6
关键词:
摘要: Mammary gland morphology and physiology are supported by an underlying cellular differentiation hierarchy. Molecular features associated with particular cell types along this hierarchy may contribute to the biological clinical heterogeneity observed in human breast carcinomas. Investigating normal developmental phenotypes tumors provide new prognostic paradigms, identify targetable pathways, explain cancer subtype etiology. We used transcriptomic profiles coming from fluorescence-activated sorted (FACS) mammary epithelial several independent murine studies. Using a meta-analysis approach, we derived consensus gene signatures for both species these relate phenotypes. then compiled dataset of patients treated neoadjuvant anthracycline taxane chemotherapy regimens determine if traits predict likelihood pathological complete response (pCR) multivariate logistic regression analysis markers genomic such as proliferation. Most tumor subtypes shared some, but not all, specific FACS-purified type; thus most potential distinct type ‘origin’ could be assigned. found that luminal progenitor mouse fetal stem predicted pCR sensitivity across all even after controlling intrinsic subtype, proliferation, variables. This work identifies clinically relevant highlights value biology perspective uncovering relationships between their counterparts.
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Aleix Prat, Olga Karginova, Joel S. Parker, Cheng Fan, Xiaping He, Lisa Bixby, J. Chuck Harrell, Erick Roman, Barbara Adamo, Melissa Troester, Charles M. Perou, Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes. Breast Cancer Research and Treatment. ,vol. 142, pp. 237- 255 ,(2013) , 10.1007/S10549-013-2743-3
Peter J. Rousseeuw, Silhouettes: a graphical aid to the interpretation and validation of cluster analysis Journal of Computational and Applied Mathematics. ,vol. 20, pp. 53- 65 ,(1987) , 10.1016/0377-0427(87)90125-7
J. Chuck Harrell, Aleix Prat, Joel S. Parker, Cheng Fan, Xiaping He, Lisa Carey, Carey Anders, Matthew Ewend, Charles M. Perou, Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse Breast Cancer Research and Treatment. ,vol. 132, pp. 523- 535 ,(2012) , 10.1007/S10549-011-1619-7
Corbin E. Meacham, Sean J. Morrison, Tumour heterogeneity and cancer cell plasticity Nature. ,vol. 501, pp. 328- 337 ,(2013) , 10.1038/NATURE12624
Mona Shehata, Andrew Teschendorff, Gemma Sharp, Nikola Novcic, I Alasdair Russell, Stefanie Avril, Michael Prater, Peter Eirew, Carlos Caldas, Christine J Watson, John Stingl, None, Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland Breast Cancer Research. ,vol. 14, pp. 1- 19 ,(2012) , 10.1186/BCR3334
Christina Curtis, Sohrab P Shah, Suet-Feung Chin, Gulisa Turashvili, Oscar M Rueda, Mark J Dunning, Doug Speed, Andy G Lynch, Shamith Samarajiwa, Yinyin Yuan, Stefan Gräf, Gavin Ha, Gholamreza Haffari, Ali Bashashati, Roslin Russell, Steven McKinney, METABRIC Group Co-chairs Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 c, Writing committee Curtis† Christina 15 16 Shah Sohrab P. 17 18 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 e, Steering committee Brenton James D. 15 16 Ellis Ian 19 Huntsman David 17 18 Pinder Sarah 20 Purushotham Arnie 20 Murphy Leigh 21 Caldas Carlos Aparicio Samuel saparicio@ bccrc. ca 17 18 j, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Chia Steven 18 Gelmon Karen 18 Huntsman David 17 18 McKinney Steven 17 18 Speers Caroline 18 Turashvili Gulisa 17 18 Watson Peter 17 18 21, University of Nottingham Ellis Ian 19 Blamey Roger 19 Green Andrew 19 Macmillan Douglas 19 Rakha Emad 19, King’s College London Purushotham Arnie 20 Gillett Cheryl 20 Grigoriadis Anita 20 Pinder Sarah 20 de Rinaldis Emanuele 20 Tutt Andy 20, Manitoba Institute of Cell Biology Murphy Leigh 21 Parisien Michelle 21 Troup Sandra 21, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Turashvili Gulisa 17 18 Bell Lynda 18 Chow Katie 18 Gale Nadia 18 Huntsman David 17 18 Kovalik Maria 18 Ng Ying 18 Prentice Leah 18, British Columbia Cancer Agency Aparicio Samuel saparicio@ bccrc. ca 17 18 b Shah Sohrab P. 17 18 Bashashati Ali 17 Ha Gavin 17 Haffari Gholamreza 17 McKinney Steven 17 18, None, The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups Nature. ,vol. 486, pp. 346- 352 ,(2012) , 10.1038/NATURE10983
Sanjay Chandriani, Eirik Frengen, Victoria H. Cowling, Sarah A. Pendergrass, Charles M. Perou, Michael L. Whitfield, Michael D. Cole, A Core MYC Gene Expression Signature Is Prominent in Basal-Like Breast Cancer but Only Partially Overlaps the Core Serum Response PLoS ONE. ,vol. 4, pp. e6693- ,(2009) , 10.1371/JOURNAL.PONE.0006693
J. H. Taube, J. I. Herschkowitz, K. Komurov, A. Y. Zhou, S. Gupta, J. Yang, K. Hartwell, T. T. Onder, P. B. Gupta, K. W. Evans, B. G. Hollier, P. T. Ram, E. S. Lander, J. M. Rosen, R. A. Weinberg, S. A. Mani, Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 15449- 15454 ,(2010) , 10.1073/PNAS.1004900107
Anne-Pierre Morel, George W. Hinkal, Clémence Thomas, Frédérique Fauvet, Stéphanie Courtois-Cox, Anne Wierinckx, Mojgan Devouassoux-Shisheboran, Isabelle Treilleux, Agnès Tissier, Baptiste Gras, Julie Pourchet, Isabelle Puisieux, Gareth J. Browne, Douglas B. Spicer, Joël Lachuer, Stéphane Ansieau, Alain Puisieux, EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice. PLOS Genetics. ,vol. 8, ,(2012) , 10.1371/JOURNAL.PGEN.1002723
Aleix Prat Aparicio, Ana Lluch Hernández, Joan Albanell Mestres, WT Barry, Cheng Fan, José Ignacio Chacón, Joel S Parker, L Calvo, A Plazaola, Angels Arcusa, Miquel A Seguí, O Burgues, N Ribelles, Álvaro Rodríguez-Lescure, A Guerrero, Manuel Ruiz-Borrego, Blanca Munárriz, JA López, Barbara Adamo, Maggie CU Cheang, Y Li, Z Hu, ML Gulley, Maria José Vidal, BN Pitcher, MC Liu, ML Citron, Matthew J Ellis, Elaine R Mardis, T Vickery, CA Hudis, EP Winer, Lisa A Carey, Rosalía Caballero, Eva Carrasco, M Martín, Charles M Perou, Emilio Alba, None, Predicting response and survival in chemotherapy-treated triple-negative breast cancer. British Journal of Cancer. ,vol. 111, pp. 1532- 1541 ,(2014) , 10.1038/BJC.2014.444