Genetic variants of methionine metabolism and DNA methylation.
作者： Stefan Bleich , Alexander Semmler , Helge Frieling , L Thumfart , Marc Muschler
DOI: 10.2217/EPI.14.54
关键词:
摘要: Aim: Altered DNA methylation is associated with important and common pathologies such as cancer. The origin of altered unknown. methyl groups for are provided by methionine metabolism. This metabolism characterized a high interindividual variability, which in part explained genetic variants. Methods: In cohort 313 individuals derived from family-based study index cases cerebrovascular disease, we analyzed whether global leukocyte was age, gender, homocysteine plasma levels or functionally relevant Results: We observed an association the G-allele synthase variant c.2756A>G (D919G) (% ± 1 SD, AA: 41.3 14.9; AG: 36.4 18.2; GG: 30.8 16.9; F = 4.799; p 0.009). various types Conclusion: Our data suggest that impact on may contribute to c...
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