The methionine synthase polymorphism c.2756A↷G (D919G) is relevant for disease-free longevity

摘要: The functional polymorphism methionine synthase (MTR) c.2576A-->G (D919G) influences homocysteine and folate metabolism has been reported to be of protective function against oncological, neurodegenerative vascular diseases. We analyzed 329 healthy individuals confirm whether this might epidemiological impact on disease-free longevity. In our sample, prevalence the G-allele was significantly higher in older than younger (p=0.005) supporting thesis that MTR is beneficial Separate analysis female male subjects revealed influence genotype became relevant at a age as opposed suggesting gender-dependent effect.