One-carbon metabolism enzyme polymorphisms and uteroplacental insufficiency.
作者： Denise L.F. Furness , Michael F. Fenech , Yee T. Khong , Roberto Romero , Gustaaf A. Dekker
DOI: 10.1016/J.AJOG.2008.06.020
关键词:
摘要: Objectives This study was undertaken to test novel genetic polymorphisms involved in 1-carbon metabolism for a potential association with increased risk of developing pregnancy complications associated uteroplacental insufficiency. Study Design prospective cohort consisting 50 women at low and 93 high having complication develop. Maternal fetal DNA samples were genotyped methionine synthase ( MTR ) A2756G, reductase MTRR A66G methylenetetrahydrofolate dehydrogenase MTHFD1 G1958A. A chi squared or χ 2 analysis used compare genotypes outcome, 1-way variance linear regression genotype continuous variables. Results The 2756 G allele insufficiency P = .022, likelihood ratio=10.4) maternal homocysteine .017). A2756G polymorphism .049, ratio=6.0), but only mothers not supplementing high-dose B-vitamins. AA intrauterine growth restriction .047, ratio=5.8). Conclusion suggests the is an important factor development In addition, 1958 may be restriction.
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