Protective effect of paraoxonase activity in high-density lipoproteins against erythrocyte membranes peroxidation: a comparison between healthy subjects and type 1 diabetic patients.

摘要: High-density lipoproteins (HDL) plays a key role in the protection against oxidative damage of lipoprotein and biological membranes. The aim present study was to investigate relationship between antioxidant HDL HDL-paraoxonase (PON) activity healthy subjects type 1 diabetic patients. Moreover, ability controls patients protect and/or repair membranes from studied. were isolated 31 sex- age-matched immediately used evaluate lipid hydroperoxides HDL-PON activity. Erythrocyte obtained oxidized with 2,2-azo-bis(2-aminidinopropane)dihydrochloride then incubated presence or subjects, measurements membrane before after incubation. showed higher levels lower than subjects. protected less efficiently erythrocyte compared A negative correlation found HDL, confirming PON peroxidation suggesting that low are more exposed high positively correlated negatively These results confirm linkage suggest might be related It hypothesized decrease protective action could contribute acceleration arteriosclerosis diabetes mellitus.