Induction of cell proliferation and neuroblasts in the subgranular zone of the dentate gyrus by aqueous extract from Platycodon grandiflorum in middle-aged mice
作者： Ki-Yeon Yoo , Ok Kyu Park , In Koo Hwang , Hua Li , Shi Yong Ryu
DOI: 10.1016/J.NEULET.2008.07.057
关键词:
摘要: In the present study, we observed neurogenic effects of an aqueous extract from root Platycodon grandiflorum (EPG) in middle-aged (12-month-old) mice. For this, 100mg/kg EPG was administered orally to mice for 30 days before sacrifice and 5-bromodeoxyguanosine (BrdU) injected intraperitoneally every 8h 24h on day prior sacrifice. The increase neurogenesis estimated by immunohistochemical staining cellular proliferation markers (BrdU Ki67) a marker neuroblasts (Doublecortin, DCX). These were detected subgranular zone dentate gyrus vehicle- EPG-treated groups. number BrdU-, Ki67- DCX-positive cells group significantly increased compared that vehicle-treated group. addition, showed well-developed processes. results suggest is repeated treatment
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sci-hub.se 参考文章(29)
Christiana M Cooper-Kuhn, H Georg Kuhn, Is it all DNA repair? Methodological considerations for detecting neurogenesis in the adult brain. Developmental Brain Research. ,vol. 134, pp. 13- 21 ,(2002) , 10.1016/S0165-3806(01)00243-7
George Paxinos, Keith B. J. Franklin, The Mouse Brain in Stereotaxic Coordinates ,(2007)
Tracey J. Shors, George Miesegaes, Anna Beylin, Mingrui Zhao, Tracy Rydel, Elizabeth Gould, Neurogenesis in the adult is involved in the formation of trace memories Nature. ,vol. 410, pp. 372- 376 ,(2001) , 10.1038/35066584
Ana Garcia, Barbara Steiner, Golo Kronenberg, Anika Bick-Sander, Gerd Kempermann, Age-dependent expression of glucocorticoid- and mineralocorticoid receptors on neural precursor cell populations in the adult murine hippocampus Aging Cell. ,vol. 3, pp. 363- 371 ,(2004) , 10.1111/J.1474-9728.2004.00130.X
Kyoung-Souk KIM, Osamu EZAKI, Shinji IKEMOTO, Hiroshige ITAKURA, Effects of Platycodon Grandiflorum Feeding on Serum and Liver Lipid Concentrations in Rats with Diet-Induced Hyperlipidemia Journal of Nutritional Science and Vitaminology. ,vol. 41, pp. 485- 491 ,(1995) , 10.3177/JNSV.41.485
Ekkasit Kumarnsit, Uraporn Vongvatcharanon, Niwat Keawpradub, Pranom Intasaro, Fos-like immunoreactivity in rat dorsal raphe nuclei induced by alkaloid extract of Mitragyna speciosa. Neuroscience Letters. ,vol. 416, pp. 128- 132 ,(2007) , 10.1016/J.NEULET.2007.01.061
Claire Gensburger, Gérard Labourdette, Monique Sensenbrenner, Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro FEBS Letters. ,vol. 217, pp. 1- 5 ,(1987) , 10.1016/0014-5793(87)81230-9
Elaheh Nooshinfar, Reza Lashgari, Abbas Haghparast, Samand Sajjadi, NMDA receptors are involved in Ginkgo extract-induced facilitation on memory retention of passive avoidance learning in rats Neuroscience Letters. ,vol. 432, pp. 206- 211 ,(2008) , 10.1016/J.NEULET.2007.12.022
Da-Qing Jin, Chol Seung Lim, Jin-Young Sung, Han Gil Choi, Ilho Ha, Jung-Soo Han, Ulva conglobata, a marine algae, has neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells. Neuroscience Letters. ,vol. 402, pp. 154- 158 ,(2006) , 10.1016/J.NEULET.2006.03.068
Ji-Young Lee, Jae-Wook Yoon, Cheong-Tae Kim, Seung-Taik Lim, Antioxidant activity of phenylpropanoid esters isolated and identified from Platycodon grandiflorum A. DC Phytochemistry. ,vol. 65, pp. 3033- 3039 ,(2004) , 10.1016/J.PHYTOCHEM.2004.08.030