Vasodilatory effects and coexistence of calcitonin gene‐related peptide (CGRP) and substance P in sensory nerves of cat dental pulp
作者： B. GAZELIUS , B. EDWALL , L. OLGART , J. M. LUNDBERG , T. HÖKFELT
DOI: 10.1111/J.1748-1716.1987.TB08108.X
关键词:
摘要: Substance P (SP)- and calcitonin gene-related peptide (CGRP)-immunoreactivity (-IR) were localized by immunohistochemistry in the same nerve cell bodies trigeminal ganglia as well terminals of dental pulp. The distribution SP- CGRP-IR nerves identical pulp mainly associated with blood vessels. level pulp, measured radio-immunoassay (RIA), was 1.4 +/- 0.2 pmol g-1 wet wt, which is range that found for substance P. Local intra-arterial infusion synthetic CGRP produced vasodilatation both laser Doppler flowmetry an 125I clearance technique. effective a vasodilator when infused femtomole per minute range, SP picomole range. effect (50 fmol min-1) 10 times larger given after (15 than before it. Since two peptides coexist neurons, it suggested they contribute to vasodilation seen upon antidromic stimulation sensory nerves.
sci-hub.se 参考文章(28)
SJ Gibson, JM Polak, SR Bloom, IM Sabate, PM Mulderry, MA Ghatei, GP McGregor, JF Morrison, JS Kelly, RM Evans, Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species The Journal of Neuroscience. ,vol. 4, pp. 3101- 3111 ,(1984) , 10.1523/JNEUROSCI.04-12-03101.1984
A. C. Cuello, G. Galfre, C. Milstein, Detection of substance P in the central nervous system by a monoclonal antibody Proceedings of the National Academy of Sciences of the United States of America. ,vol. 76, pp. 3532- 3536 ,(1979) , 10.1073/PNAS.76.7.3532
Rainer Gamse, Alois Saria, Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide. European Journal of Pharmacology. ,vol. 114, pp. 61- 66 ,(1985) , 10.1016/0014-2999(85)90520-5
Anders Franco-Cereceda, Hermann Henke, Jan M. Lundberg, Josef B. Petermann, Tomas Hökfelt, Jan A. Fischer, Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: Distribution and release by capsaicin Peptides. ,vol. 8, pp. 399- 410 ,(1987) , 10.1016/0196-9781(87)90117-3
Tomohiro Matsuyama, Akio Wanaka, Shotaro Yoneda, Kazufumi Kimura, Takenobu Kamada, Samia Girgis, Iain Macintyre, Piers C. Emson, Masaya Tohyama, Two distinct calcitonin gene-related peptide-containing peripheral nervous systems: distribution and quantitative differences between the iris and cerebral artery with special reference to substance P. Brain Research. ,vol. 373, pp. 205- 212 ,(1986) , 10.1016/0006-8993(86)90332-X
BJÖRN EDWALL, BERTIL GAZELIUS, ÁRPÁD FAZEKAS, ELVAR THEODORSSON-NORHEIM, JAN M. LUNDBERG, Neuropeptide Y (NPY) and sympathetic control of blood flow in oral mucosa and dental pulp in the cat. Acta Physiologica Scandinavica. ,vol. 125, pp. 253- 264 ,(1985) , 10.1111/J.1748-1716.1985.TB07714.X
A. Saria, R. Gamse, J. Petermann, J.A. Fischer, E. Theodorsson-Norheim, J.M. Lundberg, Simultaneous release of several tachykinins and calcitonin gene-related peptide from rat spinal cord slices. Neuroscience Letters. ,vol. 63, pp. 310- 314 ,(1986) , 10.1016/0304-3940(86)90376-9
Z. Wiesenfeld-Hallin, T. Hökfelt, J.M. Lundberg, W.G. Forssmann, M. Reinecke, F.A. Tschopp, J.A. Fischer, Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat Neuroscience Letters. ,vol. 52, pp. 199- 204 ,(1984) , 10.1016/0304-3940(84)90374-4
BERTIL GAZELIUS, ERNST BRODIN, LEIF OLGART, Depletion of substance P‐like immunoreactivity in the cat dental pulp by antidromic nerve stimulation Acta Physiologica Scandinavica. ,vol. 111, pp. 319- 327 ,(1981) , 10.1111/J.1748-1716.1981.TB06743.X
J.-A. Karlsson, M.J.B. Finney, C.G.A. Persson, C. Post, Substance P antagonists and the role of tachykinins in non-cholinergic bronchoconstriction Life Sciences. ,vol. 35, pp. 2681- 2691 ,(1984) , 10.1016/0024-3205(84)90038-9