Aegle marmelos leaf extract ameliorates the cognitive impairment and oxidative stress induced by intracerebroventricular streptozotocin in male rats

摘要: Abstract Aims Aegle marmelos (L.) Correa (A. marmelos) has been used in Ayurvedic medicine as a brain tonic however its neuroprotective effect against streptozotocin (STZ) induced cognitive impairment and oxidative stress not reported yet vivo. Therefore, the present study was attempted to investigate potential of ethanolic extract A. leaves (AME) on STZ memory male rats. Main methods Albino Wistar rats were pre-treated orally with AME at doses 200 400 mg/kg for two weeks, followed by intracerebroventricular (i.c.v.) injection (3 mg/kg) day 1 3. Two weeks after administration, behavioural parameters monitored using Morris water maze task. Biochemical histopathological studies carried out three administration. The levels markers (malondialdehyde (MDA), glutathione, nitrite, catalase) neuroinflammatory mediators; tumor necrosis factor-α (TNF-α) interleukin-6 (IL-6) acetylcholinesterase (AChE) activity estimated hippocampus rat brain. Donepezil (5 mg/kg) taken standard drug. Key findings MDA, TNF-α IL-6 significantly increased while glutathione decreased STZ-treated Further, significant decrease catalase increase AChE observed indicating cholinergic hypofunction neuronal damage animals. All these alterations ameliorated dose dependent manner. Significance deficit indicates therapeutic value Alzheimer's disease (AD).