Cationic host defense (antimicrobial) peptides.
作者： Kelly L Brown , Robert EW Hancock
DOI: 10.1016/J.COI.2005.11.004
关键词:
摘要: Members of the cationic host defense (antimicrobial) peptide family are widely distributed in nature, existing organisms from insects to plants mammals and non-mammalian vertebrates. Although many demonstrate direct antimicrobial activity against bacteria, fungi, eukaryotic parasites and/or viruses, it has been established that peptides have a key modulatory role innate immune response. More recent evidence suggests effective adjuvants, synergistic with other effectors, polarize adaptive response, support wound healing. In addition, mechanisms action being unraveled, which more implementation derivatives these endogenous as therapeutic agents.
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