ECop (EGFR-Coamplified and overexpressed protein), a novel protein, regulates NF-κB transcriptional activity and associated apoptotic response in an IκBα-dependent manner

摘要: In the present study, we describe function of a novel protein, ECop (EGFR-Coamplified and overexpressed protein), in regulation NF-κB activity. Ectopic expression increases transcriptional activity by promoting nuclear translocation DNA binding NF-κB, ECop-induced activation confers cellular resistance to apoptotic challenge. knockdown cells, is suppressed due delayed IκBα degradation, which results as well decreased NF-κB. Suppression susceptibility apoptosis. These suggest that key regulator signaling, high-level, amplification-mediated expression, such occurring tumors with amplified EGFR, could contribute