The Personal Human Oral Microbiome Obscures the Effects of Treatment on Periodontal Disease

摘要: Periodontitis is a progressive disease of the periodontium with complex, polymicrobial etiology. Recent Next-Generation Sequencing (NGS) studies microbial diversity associated periodontitis have revealed strong, community-level differences in bacterial assemblages healthy or diseased periodontal sites. In this study, we used NGS approaches to characterize changes pocket after standard treatment. Despite consistent abundance certain taxa individuals whose condition improved treatment, post-treatment samples retained highest similarity pre-treatment from same individual. Deeper phylogenetic analysis pathogen-containing genera Prevotella and Fusobacterium found both unexpected differential treatment response among species. Our results highlight how understanding interpersonal variability microbiomes necessary for determining diseases respond disturbance.