Dietary Meat Intake in Relation to Colorectal Adenoma in Asymptomatic Women

摘要: OBJECTIVES No previous study has concurrently assessed the associations between meat intake, meat-cooking methods and doneness levels, mutagens (heterocyclic amines (HCAs) polycyclic aromatic hydrocarbons), heme iron, nitrite from colorectal adenoma in asymptomatic women undergoing colonoscopy. METHODS Of 807 eligible a cross-sectional multicenter colonoscopy screening study, 158 prevalent cases 649 controls satisfactorily completed validated food frequency questionnaires. Using an established mutagen database new iron databases, we comprehensively investigated components of that may be involved carcinogenesis. logistic regression, estimated odds ratios (ORs) 95% confidence intervals (CIs) within quartiles meat-related variables. RESULTS Red was associated positively with (OR fourth vs. first quartile = 2.02; CI 1.06-3.83; P trend 0.38). Intake pan-fried 1.72; 0.96-3.07; 0.01) HCA: 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) 1.90; 1.05-3.42; 0.07) were also increased risk adenoma. The databases yielded lower estimates than assessment methods, although two highly correlated for both exposures. Although not statistically significant, there positive CONCLUSIONS In colonoscopy, adenomas high intake red meat, HCA MeIQx. Other exposures require further investigation.