The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis

摘要: The re-emergence of tuberculosis in recent years led the World Health Organization (WHO) to launch Stop TB Strategy program. Beside repurposing existing drugs and exploring novel molecular combinations, an essential step face burden will be develop new by identifying vulnerable bacterial targets. Recent studies have focused on decaprenylphosphoryl-d-ribose oxidase (DprE1) Mycobacterium tuberculosis, enzyme involved cell wall metabolism, for which promising molecules proved efficacy as antitubercular agents. This review summarizes state art concerning DprE1 terms structure, enzymatic activity inhibitors. is emerging one most target M. tuberculosis.