Tailoring chemical and physical properties of fibrous scaffolds from block copolyesters containing ether and thio-ether linkages for skeletal differentiation of human mesenchymal stromal cells

摘要: Bioactive scaffolds for tissue engineering call demands on new materials which can enhance traditional biocompatibility requirements previously considered clinical implantation. The current commercially available thermoplastic materials, such as poly(lactic acid) (PLA), poly(glycolic (PGA), poly(e-caprolactone) (PCL) and their copolymers, have been used to fabricate regenerative medicine. However, these polymers limitations including lacking of broadly tuning mechanical degradable properties, activation specific cell-scaffold interactions, limit further application in engineering. In the present study, electrospun were successfully fabricated from a class block poly(butylene succinate)-based (PBS-based) copolyesters containing either butylene thiodiglycolate (BTDG) or diglycolate (BDG) sequences. polyesters displayed tunable properties hydrolysis rate depending molecular architecture kind heteroatom introduced along polymer backbone. To investigate potential skeletal regeneration, human mesenchymal stromal cells (hMSCs) cultured basic, osteogenic chondrogenic media. Our results demonstrated that PBS-based thio-ether linkages (i.e. BTDG segments) more favorable chondrogenesis hMSCs than those ether BDG sequences). contrast, showed enhanced mineralization. Therefore, functional might hold osteochondral applications.