LAPONITE® nanorods regulating degradability, acidic-alkaline microenvironment, apatite mineralization and MC3T3-E1 cells responses to poly(butylene succinate) based bio-nanocomposite scaffolds

摘要: Novel bio-nanocomposite scaffolds for bone tissue engineering were prepared by incorporation of LAPONITE® (LAP) nanorods into poly(butylene succinate) (PBSu). The results showed that the had well interconnected macroporous structures with macropore size in range 200–400 μm and porosity around 70%. In addition, water absorption, degradability apatite mineralization ability clearly enhanced increase LAP content. Moreover, degradation produced alkaline products, which neutralized acidic degradable products PBSu, formed a weak microenvironment similar to biological environment. Furthermore, adhesion, proliferation differentiation MC3T3-E1 cells onto significantly promoted content, scaffold 30 wt% (sPL30) exhibited best stimulation effect on responses. suggested promotion responses could be ascribed improvements surface characteristics (including roughness, hydrophilicity, ions release formation, etc.) scaffolds. sPL30 excellent biocompatibility, bioactivity great potential applications engineering.