Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

摘要: Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H2: constitutive COX-1 and inducible COX-2. To assess the role COX-2 in colorectal tumorigenisis, we determined effects gene (Ptgs2) knockouts a novel inhibitor on Apc delta716 knockout mice, model human familial adenomatous polyposis. A Ptgs2 null mutation reduced number size intestinal polyps dramatically. Furthermore, treating mice with polyp more significantly than sulindac, which inhibits both isoenzymes. These results provide direct genetic evidence that plays key tumorigenesis indicate COX-2-selective inhibitors can be class therapeutic agents for polyposis cancer.