System and method for high-throughput assessment of cellular cardiotoxicity, drug screening, and cardiogenic factors via online physiological measurements
作者： Kacey Ronaldson , Gordana Vunjak-Novakovic , Nina Tandon , Elisa Cimetta
DOI:
关键词:
摘要: An integrated system for detecting safety and/or efficacy issues related to potential drug compounds by combining tissue maturation, imaging and electrophysiology measurements, at high throughput, with signal noise ratio. Testing includes cardiotoxicity screening, screening cardiogenic factors via on-line physiological measurements.
lens.org 参考文章(8)
Tadayasu Matsushita Elec.Ind.Co. Ltd. Mitsumata, Akihito Matsushita Elec. Ind. Co. Ltd. Kamei, Makoto Matsushita Elec. Ind. Co. Ltd. Taketani, Hirokazu Matsushita Elec. Ind. Co. Ltd Sugihara, Yasushi Matsushita Elec. Ind. Co. Ltd. Kobayashi, Cell potential measurement apparatus having a plurality of microelectrodes ,(1995)
Miroslava Josowicz, Jiri Janata, George Yang Yu, Electrochemical biosensor arrays and instruments and methods of making and using same ,(2008)
J. Gary Eden, Sung-Jin Park, Method to manufacture reduced mechanical stress electrodes and microcavity plasma device arrays ,(2012)
Lior Gepstein, Joseph Itskovitz-Eldor, Izhak Kehat, Michal Amit, Methods of generating human cardiac cells and tissues and uses thereof ,(2002)
Laurent Giovangrandi, Gregory T. A. Kovacs, Low cost fabrication of microelectrode arrays for cell-based biosensors and drug discovery methods ,(2005)
Swaminathan Rajaraman, Mark G. Allen, Bruce Wheeler, Edgar A. Brown, James Ross, Apparatus and methods for high throughput network electrophysiology and cellular analysis ,(2009)
Janos Vörös, Beat Keller, Clarence Tang, Marcus Textor, Electrochemical patterning on multi-channel microelectrode array for biosensing applications ,(2004)
Kenji Yasuda, Fumimasa Nomura, Tomoyuki Kaneko, Method and device for myocardial cell evaluation and myocardial toxicity inspection ,(2011)