The glyoxylate cycle is required for temporal regulation of virulence by the plant pathogenic fungus Magnaporthe grisea

摘要: Summary We describe the isolation and characterization of ICL1 from rice blast fungus Magnaporthe grisea , a gene that encodes isocitrate lyase, one principal enzymes glyoxylate cycle. shows elevated expression during development infection struc- tures cuticle penetration, targeted replacement showed is required for full virulence by M. . In particular, we found prepenetration stage development, before entry into plant tissue, affected loss There delay in germination, infection- related penetration D icl1 mutants. Recent reports have shown importance cycle human pathogenic Candida albicans bacterial pathogen Mycobacterium tuberculosis Our results indicate also impor- tant this fungus, demonstrating widespread utility pathway microbial pathogenesis.