The low molecular weight (LMW) isoforms of cyclin E deregulate the cell cycle of mammary epithelial cells.
作者： Isabelle Bedrosian , Said Akli , Khandan Keyomarsi , Hannah Wingate
DOI: 10.4161/CC.2.5.464
关键词:
摘要: Cyclin E is a positive regulator of the G1 to S phase transition cell cycle. In complex with CDK2 it responsible for cells passing restriction point, committing another round division. overexpressed and proteolytically cleaved into low molecular weight (LMW) isoforms in breast cancer lines tumor tissues compared normal tissues. These alterations cyclin are linked poor prognosis patients. Our laboratory has determined that LMW forms generated post-translationally, via elastase mediated cleavage at 2 specific sites amino-terminus full length E. order evaluate biological effects E, immortalized mammary epithelial cells, 76NE6, were stably transfected each three constructs. results reveal (T1 T2) biologically functional, as their overexpression increases abi...
sci-hub.se 参考文章(40)
William Renyifo Cam, Tsutomu Masaki, Yasushi Shiratori, Naoya Kato, Makoto Okamoto, Yutaka Yamaji, Kouichi Igarashi, Takaaki Sano, Masao Omata, Activation of Cyclin E-Dependent Kinase Activity in Colorectal Cancer Digestive Diseases and Sciences. ,vol. 46, pp. 2187- 2198 ,(2001) , 10.1023/A:1011962915280
K. Keyomarsi, W. Toyofuku, M. P. Fox, D. Conte, Deregulation of cyclin E in breast cancer Oncogene. ,vol. 11, pp. 941- 950 ,(1995)
Charles H. Spruck, Kwang-Ai Won, Steven I. Reed, Deregulated cyclin E induces chromosome instability Nature. ,vol. 401, pp. 297- 300 ,(1999) , 10.1038/45836
Nicolai Maass, Zhiqiang Zou, Zhiqiang Zou, Ruth Sager, Ming Zhang, Differential expression of elafin in human normal mammary epithelial cells and carcinomas is regulated at the transcriptional level Cancer Research. ,vol. 55, pp. 2537- 2541 ,(1995)
Vimla Band, James A De Caprio, Laurie Delmolino, Victoria Kulesa, Ruth Sager, None, Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. Journal of Virology. ,vol. 65, pp. 6671- 6676 ,(1991) , 10.1128/JVI.65.12.6671-6676.1991
Khandan Keyomarsi, Donald C. Porter, Richard M. Harwell, Richard M. Harwell, Christopher Danes, Processing of cyclin E differs between normal and tumor breast cells. Cancer Research. ,vol. 60, pp. 481- 489 ,(2000)
D Resnitzky, M Gossen, H Bujard, S I Reed, Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Molecular and Cellular Biology. ,vol. 14, pp. 1669- 1679 ,(1994) , 10.1128/MCB.14.3.1669
Charles J. Sherr, The Pezcoller lecture: cancer cell cycles revisited. Cancer Research. ,vol. 60, pp. 3689- 3695 ,(2000)
Peggy L. Porter, Kathleen E. Malone, Patrick J. Heagerty, Gail M. Alexander, Laura A. Gatti, Eduardo J. Firpo, Janet R. Daling, James M. Roberts, Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nature Medicine. ,vol. 3, pp. 222- 225 ,(1997) , 10.1038/NM0297-222
U. Westin, M. Nyström, I. Ljungcrantz, B. Eriksson, K. Ohlsson, The presence of elafin, SLPI, IL1-RA and STNFalpha RI in head and neck squamous cell carcinomas and their relation to the degree of tumour differentiation. Mediators of Inflammation. ,vol. 11, pp. 7- 12 ,(2002) , 10.1080/09629350210304