Cross‐reactivity among fungal allergens: a clinically relevant phenomenon?

摘要: Summary Atopic patients suffering from allergic asthma, rhinitis, or atopic eczema oftenhave detectable levels of serum IgE antibodies to fungi. Although the associationbetween fungal sensitisation and different forms diseases, including allergicasthma life-threatening bronchopulmonary aspergillosis, is wellestablished, clinical relevance cross-reactivity among speciesremains largely unknown. Recent progress in molecular cloning allergensand availability more than 40 completely sequenced genomes facilitatescharacterisation, cloning, production highly pure recombinant allergens,identification homologous orthologous allergens widespread fungalkingdom, silico prediction, experimental vitro vivo verification between pan-allergens. These studies indicate that an important component sensitisation. Key words: Fungi, allergens, allergy, cross-reactivity, structure, relevance.