Integrins-FAK-Rho GTPases pathway in endothelial cells sense and response to surface wettability of plasma nanocoatings.
作者： Yang Shen , Yunlong Ma , Min Gao , Yi Lai , Guixue Wang
DOI: 10.1021/AM400973A
关键词:
摘要: Vascular endothelial cell (EC) adhesion and migration are essential processes in re-endothelialization of implanted biomaterials, which affected by surface properties materials such as wettability. Our previous study demonstrated that, model substrates, EC adhesion/migration showed an opposite behavior on the hydrophobic hydrophilic surfaces plasma SiOx:H nanocoatings. Extending our works, expression distribution crucial proteins integrins-FAK-Rho GTPases signaling pathways were examined, respectively. The results that a could enhance focal protein associated with adhesion; however, improve Rho phosphorylation level FAK, revealing potential reason wettability mediating different cells’ behaviors. These findings reveal relationship molecular mechanism end...
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