Smooth muscle cell markers in developing rat lung.

摘要: We employed a panel of antibodies directed against cytoskeletal and contractile proteins in developmental study to follow the differentiation distribution smooth muscle-like cells rat lung. observed that, mesenchyme around developing airways vessels, desmin replaces vimentin as predominant intermediate filament specialization toward muscle occurs. Normally, myosin were expressed together their acquisition appeared indicative terminal muscle. In this regard, maturation vascular is delayed lung relative that surrounding air passages. alpha-smooth actin-containing form thicker coat primitive airway tubes extend farther down tree than or myosin-positive cells. This suggests alpha-actin marker for initial these arise from enveloping mesenchyme. pseudoglandular canalicular lung, alpha-actin-containing also found regions epithelial tube cleft formation, suggesting an association with process branching morphogenesis. addition, large complement alpha-actin-positive but myosin-negative saccular interstitium during period secondary saccule formation capillary reorganization leads final alveolarization. summary, we note muscle-like, areas periods remodeling normal pulmonary development. observation may have relevance repair adult