Synthesis of basement membrane proteins by rat mammary epithelial cells

作者: E.Jane Ormerod , Michael J. Warburton , Christine Hughes , Philip S. Rudland

DOI: 10.1016/0012-1606(83)90328-7

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摘要: A mammary epithelial cell line, Rama 25, growing on plastic, deposits fibronectin, type IV collagen, and laminin in punctate structures located beneath the basal surface of cells. When grown collagen gels, 25 cells deposit these basement membrane proteins a continuous layer between matrix. also penetrate matrix forming rudimentary duct-like structures. These are surrounded by discontinuous proteins. The ducts fetal neonatal rat glands contain few mature myoepithelial our results suggest that some cells, contact with collagenous stroma, capable synthesizing lamina-like structure.

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