Plasma albumin levels correlate with decreased microcirculation and the development of skin defects in hemodialyzed patients

摘要: Abstract Objectives Difficulty healing wounds and skin defects is a frequent problem in patients on chronic hemodialysis (HD) because of malnutrition, inflammation, atherosclerosis (MIA) syndrome. The aim the present study was to estimate influence peripheral blood flow changes during HD development foot its relationship plasma albumin levels. Methods Peripheral measured using laser Doppler line scanner 10 different areas dorsal part instep toes each before with ultrafiltration (897 ± 465 mL/procedure) 31 (10 female, 21 male; age 36-79 y, body mass index = 28 5.0). No or apparent acute disease infection were detected any patient at time measurement. feet clinically re-examined carefully over next 18 mo. Results We found significant constant decrease procedure ( P r 0.36, 0.05) 0.47, 0.007). Skin developed 11 patients, significantly lower 18-mo follow-up period. A larger number who had normal perfusion remained defect-free comparison critical (93% versus 38%, 0.002, Kaplan-Meier analysis). Conclusion may be impaired patients. malnutrition inflammation are likely responsible for decreased difficulty heal wounds.