Oxygen is required to restore flor strain viability and lipid biosynthesis under fermentative conditions

摘要: To further elucidate the biosynthesis of lipids in flor strains under fermentative conditions, transcription levels lipid biosynthetic genes ACS1, ACS2, ACC1, OLE1, ERG1, ERG11, ARE1 and ARE2, as well composition cell viability a strain were compared with that non-flor during hypoxic aerobic fermentations absence nutrients. While no significant differences or compositions observed between two when oxygen was not limiting, seen fermentation. In this last condition, strain, spite higher genes, lost abilities to desaturate fatty acids complete ergosterol biosynthesis, showed dramatic loss viability. contrast, which lower levels, able reach balanced maintained One possible explanation is requires amount than order carry out oxygen-dependent steps conditions.