Myelin Proteolipid Protein Expression in Normal and Jimpy Mice
作者： Wendy B. Macklin , Minnetta V. Gardinier , Prescott L. Deninger , Barbara A. Sorg , Celia W. Campagnoni
DOI: 10.1007/978-1-4757-0354-2_3
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摘要: The myelin membrane is a highly specialized extension of the oligo-dendroglial plasma membrane, which surrounds axons and forms tightly compacted multilamellar structure (Peters et al., 1970). Myelin integrity essential for normal nervous system function, understanding mechanism formation important because large number clinical problems observed when altered (Adams Victor, Oligodendrocyte differentiation have become developmental to investigate at molecular level several reasons. occurs over narrow time period during brain development, indicating that it developmentally regulated. Since has somewhat simple protein composition, with proteolipid (PLP) basic (MBP) comprising 70–80% adult CNS (Eng 1968; Norton Poduslo, 1973) major portion oligodendrocyte program dedicated synthesis these two groups proteins.
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