Trajectories and Predictors of Longitudinal Preexposure Prophylaxis Adherence Among Men Who Have Sex With Men.

摘要: Author(s): Pasipanodya, Elizabeth C; Jain, Sonia; Sun, Xiaoying; Blumenthal, Jill; Ellorin, Eric; Corado, Katya; Dube, Michael P; Daar, Eric S; Morris, Sheldon R; Moore, David J; California Collaborative Treatment Group (CCTG) TAPIR Study Team | Abstract: BackgroundAdherence is necessary for efficacy of preexposure prophylaxis (PrEP), and text-messaging methods are promising tools both adherence assessment support. Although PrEP variable, little research has examined patterns variability or factors associated with longitudinal use.MethodsIn the context a randomized controlled trial versus standard care adherence, 181 men who have sex received once-daily tenofovir disoproxil fumarate/emtricitabine daily texts 48 weeks. Growth mixture modeling (GMM) was used to identify subgroups individuals similar trajectories text-reported adherence. Between-group differences in pharmacologic measures (ie, diphosphate emtricitabine triphosphate levels), as well predictors study-end attitudes group membership, were examined.ResultsGMM identified 4 Classes higher had drug concentrations. Younger age minority race lower classes greater baseline levels depression, substance use concerns, sexual risk. Differences study satisfaction also adherence.ConclusionsThis supports Identifying less-than-optimal may aid clinicians anticipating at-risk patients requiring augmented intervention.Clinical trials registrationNCT01761643.