Glioneuronal Tumors and Epilepsy: Clinico-Diagnostic Features and Surgical Strategies

摘要: Glioneuronal tumors (GNTs) are a set of the Central Nervous System (CNS) composed entirely or partially cells with neuronal differentiation. The description applies to several referred in Classification World Health Organization (WHO) as and mixed neuronal-glial tumors. Some them arise tipically cerebral cortex represent common cause drug-resistant focal epilepsies children young adults. Three groups considerable relevance: ganglion cell (GCTs), ganglioglioma (GG) being typical example, dysembryoplastic neuroepithelial (DNTs) neurocytic tumors, namely extraventricular neurocytoma. GNTs commonly from housing developmental malformations, that able provoke seizures, such cortical dysplasia (FCD) and, less frequently, hyppocampal sclerosis (HS). Management patients includes dealing both tumor epilepsy. From neuro-oncological point view, consistently long clinical history, these generally considered low-grade gliomas (LGGs). They correspond grades I II WHO classification their therapy relies mainly on surgery. However, progression transformation into higher grade may occur.