Intracranial ganglioglioma: preoperative characteristics and oncologic outcome after surgery.

摘要: In order to investigate the clinical characteristics, neuroimaging findings, pathological features, treatment, and outcomes, provide valuable guidance for diagnosis management of intracranial gangliogliomas, 34 cases gangliogliomas were retrospectively analyzed. This study included 23 males 11 females. Age at operation ranged from 17 days 50 years. All patients had preoperative magnetic resonance imaging (MRI). Computed tomography (CT), spectroscopy (MRS), 18F-FDG–PET (positron emission tomography), 99Tc-HMPAO-SPECT (single photon computed tomography) also performed in some cases. specimens all available neuroimages re-evaluated. The follow-up period varied 12 89 months (mean 36 months). Seizure was most common presenting symptom (85%). Tumor calcification detected by CT scan six Seventeen (50%) showed cystic components 18 tumors (53%) enhanced on MRI. temporal lobe located intracortically them poor demarcation comparison with contralateral normal area, a reduced Cho/Cr NAA/Cr ratio, an increased Cho/NAA ratio. On 18F-FDG-PET, usually hypometabolic. HMPAO-SPECT indicated tumor hypoperfusion or isoperfusion. A gross total resection achieved 25 patients. progression observed three who underwent incomplete resection. Two malignant transformation glioblastoma. Twenty-seven could carry their life activity Karnofsky Performance Scale (KPS) more than 80. Even though ganglioglioma is slowly growing benign tumor, which be demonstrated PET, SPECT, there chance transformation, especially Gangliogliomas should resected totally, if feasible, achieve best long-term outcomes.