Skin absorption studies of octyl-methoxycinnamate loaded poly(D,L-lactide) nanoparticles: estimation of the UV filter distribution and release behaviour in skin layers.
作者： M Vettor , S Bourgeois , H Fessi , Jean Pelletier , Paola Perugini
DOI: 10.3109/10717540903097770
关键词:
摘要: New formulation strategies have to be developed limit the skin penetration of UV-filter. Nanoparticles (NP) are very suitable for that purpose. In this study, distribution, at different times (1, 2 and 3 h), octyl-methoxycinnamate (OMC) from loaded PLA-nanoparticles was compared a classical containing non-encapsulated OMC, using Franz cell method. The results showed OMC clearly impeded by stratum corneum major part OMC-NP accumulated surface (480%). A significant lower amount quantified in viable with NP emulgel. To accurately determine real close contact layers two solvents were used extract compartments. Acetone (ACET) allowed quantifying both released particles, while isopropylmyristate (IPM), non-solvent polymer (PLA), only particles. Using IPM as an extraction solvent, it appeared NP, skin, 3-fold than free diffused Lastly, sustained release observed when nanoparticles used.
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M. S. Roberts, K. Walters, Percutaneous absorption of sunscreens Drugs and the pharmaceutical sciences. ,vol. 97, pp. 681- 700 ,(2005)
Vinod K Gupta, Joel L Zatz, Mark Rerek, None, Percutaneous absorption of sunscreens through micro-yucatan pig skin in vitro. Pharmaceutical Research. ,vol. 16, pp. 1602- 1607 ,(1999) , 10.1023/A:1018916907263
Otto Braun-Falco, Gerd Plewig, Helmut H. Wolff, Walter H. C. Burgdorf, Diseases Caused by Environmental Exposure or Trauma Springer Berlin Heidelberg. pp. 521- 569 ,(2000) , 10.1007/978-3-642-97931-6_13
U. Edlund, A. -C. Albertsson, Degradable polymer microspheres for controlled drug delivery Advances in Polymer Science. ,vol. 157, pp. 67- 112 ,(2002) , 10.1007/3-540-45734-8_3
R. Alvarez-Román, A. Naik, Y.N. Kalia, R.H. Guy, H. Fessi, Skin penetration and distribution of polymeric nanoparticles Journal of Controlled Release. ,vol. 99, pp. 53- 62 ,(2004) , 10.1016/J.JCONREL.2004.06.015
F. Benech-Kieffer, P. Wegrich, R. Schwarzenbach, G. Klecak, T. Weber, J. Leclaire, H. Schaefer, Percutaneous Absorption of Sunscreens in vitro: Interspecies Comparison, Skin Models and Reproducibility Aspects Skin Pharmacology and Applied Skin Physiology. ,vol. 13, pp. 324- 335 ,(2000) , 10.1159/000029940
B.L. Diffey, Sunscreens and melanoma: the future looks bright. British Journal of Dermatology. ,vol. 153, pp. 378- 381 ,(2005) , 10.1111/J.1365-2133.2005.06729.X
Blanca I. Olvera-Martínez, Jennyfer Cázares-Delgadillo, Silvia B. Calderilla-Fajardo, Rafael Villalobos-García, Adriana Ganem-Quintanar, David Quintanar-Guerrero, Preparation of polymeric nanocapsules containing octyl methoxycinnamate by the emulsification–diffusion technique: Penetration across the stratum corneum Journal of Pharmaceutical Sciences. ,vol. 94, pp. 1552- 1559 ,(2005) , 10.1002/JPS.20352
A.K. Kohli, H.O. Alpar, Potential use of nanoparticles for transcutaneous vaccine delivery: effect of particle size and charge International Journal of Pharmaceutics. ,vol. 275, pp. 13- 17 ,(2004) , 10.1016/J.IJPHARM.2003.10.038
M. Vettor, P. Perugini, S. Scalia, B. Conti, I. Genta, T. Modena, F. Pavanetto, Poly(D,L-lactide) nanoencapsulation to reduce photoinactivation of a sunscreen agent. International Journal of Cosmetic Science. ,vol. 30, pp. 219- 227 ,(2008) , 10.1111/J.1468-2494.2008.00443.X