Fatty Acid Binding Proteins and Cardiovascular Risk
作者： Teresa M. Pérez-Sanz , Daniel A. de Luis
DOI: 10.1007/S12170-012-0287-4
关键词:
摘要: The role of fatty acid-binding proteins in cardiovascular disease has been the subject several studies and viewpoints recent years. These are involved atherosclerotic plaque formation mainly macrophages through a complex processing lipids inflammatory responses. In addition, they may signal presence obesity, insulin resistance, type 2 diabetes mellitus, co-morbidities with demonstrated impact risk. present review aims to summarize most relevant findings over past years function (FABPs) along spectrum metabolic disorders disease. Finally, we will discuss potential use FABPs as risk markers therapeutic targets halt progression atherosclerosis.
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Liza Makowski, Jeffrey B. Boord, Kazuhisa Maeda, Vladimir R. Babaev, K. Teoman Uysal, Maureen A. Morgan, Rex A. Parker, Jill Suttles, Sergio Fazio, Gökhan S. Hotamisligil, MacRae F. Linton, Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis Nature Medicine. ,vol. 7, pp. 699- 705 ,(2001) , 10.1038/89076
Jose M. Ordovas, Identification of a functional polymorphism at the adipose fatty acid binding protein gene (FABP4) and demonstration of its association with cardiovascular disease: a path to follow. Nutrition Reviews. ,vol. 65, pp. 130- 134 ,(2007) , 10.1111/J.1753-4887.2007.TB00290.X
Masato Furuhashi, Shutaro Ishimura, Hideki Ota, Manabu Hayashi, Takahiro Nishitani, Marenao Tanaka, Hideaki Yoshida, Kazuaki Shimamoto, Gökhan S. Hotamisligil, Tetsuji Miura, Serum Fatty Acid-Binding Protein 4 Is a Predictor of Cardiovascular Events in End-Stage Renal Disease PLoS ONE. ,vol. 6, pp. e27356- ,(2011) , 10.1371/JOURNAL.PONE.0027356
Roshanak Bagheri, Atif N. Qasim, Nehal N. Mehta, Karen Terembula, Shiv Kapoor, Seth Braunstein, Mark Schutta, Nayyar Iqbal, Michael Lehrke, Muredach P. Reilly, Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus. American Journal of Cardiology. ,vol. 106, pp. 1118- 1123 ,(2010) , 10.1016/J.AMJCARD.2010.06.028
Maximilian von Eynatten, Lutz P. Breitling, Marcel Roos, Marcus Baumann, Dietrich Rothenbacher, Hermann Brenner, Circulating Adipocyte Fatty Acid-Binding Protein Levels and Cardiovascular Morbidity and Mortality in Patients With Coronary Heart Disease A 10-year Prospective Study Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 32, pp. 2327- 2335 ,(2012) , 10.1161/ATVBAHA.112.248609
Dennis CY Yeung, Yu Wang, Aimin Xu, Stephen CW Cheung, Nelson MS Wat, Daniel YT Fong, Carol HY Fong, MT Chau, Pak C Sham, Karen SL Lam, Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio- metabolic risk factors and carotid atherosclerosis European Heart Journal. ,vol. 29, pp. 2156- 2163 ,(2008) , 10.1093/EURHEARTJ/EHN295
Masato Furuhashi, Gökhan S. Hotamisligil, Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nature Reviews Drug Discovery. ,vol. 7, pp. 489- 503 ,(2008) , 10.1038/NRD2589
G Tuncman, E Erbay, X Hom, I De Vivo, H Campos, Eric Bruce Rimm, GS Hotamisligil, None, A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 6970- 6975 ,(2006) , 10.1073/PNAS.0602178103
Maria Luisa Mansego, Fernando Martínez, Maria Teresa Martínez-Larrad, Carina Zabena, Gemma Rojo, Sonsoles Morcillo, Federico Soriguer, Juan Carlos Martín-Escudero, Manuel Serrano-Ríos, Josep Redon, Felipe Javier Chaves, Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0031853
Angeliki Georgopoulos, Hanna Bloomfield, Dorothea Collins, Margaret E. Brousseau, Jose M. Ordovas, John J. O’Connor, Sander J. Robins, Ernest J. Schaefer, Codon 54 polymorphism of the fatty acid binding protein (FABP) 2 gene is associated with increased cardiovascular risk in the dyslipidemic diabetic participants of the veterans affairs HDL intervention trial (VA-HIT) Atherosclerosis. ,vol. 194, pp. 169- 174 ,(2007) , 10.1016/J.ATHEROSCLEROSIS.2006.07.022